Engineered human hepatocyte organoids enable CRISPR-based target discovery and drug screening for steatosis
FOXO transcription factors as mediators of stress adaptation. M.J. Rodríguez Colman, T.B. Dansen and B.M.T. Burgering. Nature Reviews Molecular Cell Biology Volume 25, Issue 1, January 2024, Page 46–64. https://doi.org/10.1038/s41580-023-00649-0
Rewiring glucose metabolism improves 5-FU efficacy in p53-deficient/KRASG12D glycolytic colorectal tumors. M.C. Ludikhuize, S. Gevers, N.T.B. Nguyen, M. Meerlo, S.K.S. Roudbari, M. Can Gulersonmez, E.C.A. Stigter, J. Drost, H.C. Clevers, B.M.T. Burgering and M.J. Rodríguez Colman. Communications Biology. Volume 5, 31 October 2022, Page 1159. https://doi.org/10.1038/s42003-022-04055-8
Protocol to profile the bioenergetics of organoids using Seahorse. M.C. Ludikhuize, M. Meerlo, B.M.T. Burgering and M.J. Rodríguez Colman. STAR Protocols, Volume 2, Issue 1, March 19 2021, Page 100386. https://doi.org/10.1016/j.xpro.2021.100386
Mitochondria define intestinal stem cell differentiation downstream of a FOXO/Notch axis. M.C. Ludikhuize, M. Meerlo, M. Pages Gallego, M. Burgaya Julià, N.T.B. Nguyen, E. C. Brombacher, J.H. Paik, B.M. T. Burgering, M.J. Rodríguez Colman. Cell Metabolism. Volume 32, Issue 5, 3 November 2020, Pages 889-900.e7. https://doi.org/10.1016/j.cmet.2020.10.005
Metabolic Regulation of Stem Cells and Differentiation: A Forkhead Box O Transcription Factor Perspective. M.C. Ludikhuize and M.J. Rodríguez Colman. Antioxidants & Redox Signaling. Vol. 34, No. 13, Metabolic Redox-Switches and Moonlighting Proteins. 7 Apr 2021 https://doi.org/10.1089/ars.2020.8126
Interplay between metabolic identities in the intestinal crypt supports stem cell function. Rodríguez-Colman MJ, Schewe M, Meerlo M, Stigter E, Gerrits J, Pras-Raves M, Sacchetti A, Hornsveld M, Oost KC, Snippert HJ, Verhoeven-Duif N, Fodde R, Burgering BM. Nature. 2017 Mar 16;543(7645):424-427. doi: 10.1038/nature21673. Epub 2017 Mar 8. https://www.nature.com/articles/nature2167
FOXOs support the metabolic requirements of normal and tumor cells by promoting IDH1 expression. Charitou P*, Rodriguez-Colman M*, Gerrits J, van Triest M, Groot Koerkamp M, Hornsveld M, Holstege F, Verhoeven-Duif NM, Burgering BM. EMBO Rep. 2015 Apr;16(4):456-66. doi: 10.15252/embr.201439096. Epub 2015 Feb 3. *Shared first authorship. https://www.embopress.org/doi/full/10.15252/embr.201439096
With collaborators
Engineered human hepatocyte organoids enable CRISPR-based target discovery and drug screening for steatosis. D. Hendriks, J.F. Brouwers, K. Hamer, M.H. Geurts, L. Luciana, S. Massalini, C. López-Iglesias, P.J. Peters, M.J. Rodríguez Colman, S. Chuva de Sousa Lopes, B. Artegiani & H.C. Clevers Nature Biotechnology. Volume 41, Issue 11, November 2023, Page 1567–1581. https://doi.org/10.1038/s41587-023-01680-4
Global analysis of protein arginine methylation. Fangrong Zhang, Jakob Kerbl-Knapp, Maria J. Rodriguez Colman, …, Tobias Madl. Cell Reports Methods. 2021 Jun Vol 1, Issue 2, 100016. https://doi.org/10.1016/j.crmeth.2021.100016
Integrative multi-omics analysis of intestinal organoid differentiation. Lindeboom RG, van Voorthuijsen L, Oost KC, Rodríguez-Colman MJ, Luna-Velez MV, Furlan C, Baraille F, Jansen PW, Ribeiro A, Burgering BM, Snippert HJ, Vermeulen M. Molecular Systems Biology 2018 Jun 26;14(6):e8227. doi: 10.15252/msb.20188227. https://www.embopress.org/doi/full/10.15252/msb.20188227
Specific Labeling of Stem Cell Activity in Human Colorectal Organoids Using an ASCL2-Responsive Minigene. Oost KC, van Voorthuijsen L, Fumagalli A, Lindeboom RGH, Sprangers J, Omerzu M, Rodríguez-Colman MJ, Heinz MC, Verlaan-Klink I, Maurice MM, Burgering BMT, van Rheenen J, Vermeulen M, Snippert HJG. Cell Reports 2018 Feb 6;22(6):1600-1614. https://pubmed.ncbi.nlm.nih.gov/29425513/
Rodriguez Colman Lab 