Deciphering metabolism as a regulator of cell fate
We are interested in how cellular metabolism is intertwined with every process in the cell. We study the cross-talk between cell signalling and metabolism in the context of normal tissue homeostasis and in cancer.
The Research Models and the Tools
In our group we use cell lines and organoids. Organoids are derived from healthy and cancerous tissue and recapitulate in vitro, tissue architecture, cell heterogeneity and the cellular interactions that take place in vivo.
We apply a number of Analytics to our research:
Live imaging of genetic encoded metabolic sensors and cell signalling reporters
Seahorse-based Bioenergetic analysis
Omics-based: Metabolomics, Proteomics and RNAseq.