Online talk: Unraveling cancer metabolism with genetic encoded fluorescent based metabolic reporters

On May 10, Maria gave an online talk in the Virtual Pub/Cancer Metabolism Series with the International Society for Cancer Metabolism (ISCaM).

Abstract

Cancer is a complex disease characterized by the occurrence of genetic and phenotypic variations, that exist even within the same tumors. Unfortunately, this diversity greatly contributes to therapy resistance and tumor relapse. Tumors develop under the selective pressures imposed by the micro-environment, which includes their metabolic environment. At the same time, the metabolism of cancer cells is heavily derailed, which is one of the hallmarks of cancer, and supports their uncontrolled proliferation. Our overarching goal is to understand, at the molecular level, how metabolism and metabolic perturbations, impact on tumor diversity, development, therapy response and relapse. For our mechanistic studies, we employ human-derived organoids, that faithfully recapitulate tissue architecture and cellular dynamics. By genetically introducing fluorescent-based reporters combined with 4D live imaging, we simultaneously monitor the dynamics between cell fate and metabolic changes with high temporal and single-cell resolution. I will present our recent advances in unraveling the intricate role of lactate, originally considered a waste product of the tumor, in delineating tumors’ phenotypic and genetic diversity.

Original item at eurobioimaging.eu: https://www.eurobioimaging.eu/news/new-cancer-metabolism-series-at-the-virtual-pub-starting-may-10/